Phenytoin cream for sciatic pain

In March 2020 a milestone paper related to the peripheral pathogenesis of sciatic pain has been published by us, in collaboration with a Canadian pain specialist. Increasingly we and colleagues all over the world finder phenytoin cream quite remarbable, sometimes even in indications one would not expect phenytoin cream to…

TI presents first double-blind data supporting phenytoin 10% cream in painful polyneuropathies at FIGON Dutch Medicines Days

TI presents first double-blind data supporting phenytoin 10% cream in painful polyneuropathies at FIGON Dutch Medicines Days Every year FIGON (Federatie Innovatie Geneesmiddel Onderzoek Nederland: Dutch Federation Innovative Medicine Research) is organizing a 2-day conference. On the 23rd of September 2019 at  the FIGON Dutch Medicines Days David Kopsky on…

Topical Innovation’s strategy supported: focus on broad-acting sodium channel blocker has higher likelihood of success

Topical Innovation’s strategy supported: focus on broad-acting sodium channel blocker has higher likelihood of success Nature’s review of April 8, 2019 is a further supportive piece of evidence for Topical Innovation’s strategy of developing a broad-acting sodium channel blocker as a topical treatment for neuropathic pain. Author Kingwell points out…

Publication on topical analgesics

In the Dutch Pain Journal, “Nederlandstalig Tijdschrift Pijnbestrijding” we recently published an article about topical analgesia for the treatment of neuropathic pain. Read the whole artilce here.

English abstract

Old co-analgesics such as amitriptyline, ketamine and phenytoin are worth of being re-evaluated in compounded creams for the treatment of peripheral neuropathic pain. We call that process repositioning or repurposing. Read More…

9th International Conference on Clinical & Medical Case Reports: Keynote speech on n-of-1 case collections based on phenytoin cream in painful neuropathy

9th International Conference on Clinical & Medical Case Reports: Keynote speech on n-of-1 case collections based on phenytoin cream in painful neuropathy At the 9th International Conference on Clinical & Medical Case Reports September 27-28, 2018 at Amsterdam, the Netherlands the focus is: Role of Clinical & Medical Case Reports…

Phenytoin: a new cytoprotective mechanism

Phenytoin: a new cytoprotective mechanism An impressive group of scientists from Germany, Spain, USA and France worked on discovering a new cellular mechanism of phenytoin, a mechanism leading to cellular protection [1]. They published the results in March 2018. We have described phenytoin’s protective mechanism on the level of nerve…

New drugs for Neuropathic Pain badly needed!

New drugs for Neuropathic Pain badly needed! In Pain Medicine News of 2017 an analysis is presented of many recent meta-analysis and studies to evaluate our current painkillers in neuropathic pain. The result is actually shocking, as we need to conclude that in this field not much progress exists, and…

Topical analgesics can reduce opioid use

Topical analgesics can reduce opioid use Chronic, noncancer pain, among which neuropathic pain affects around 200 million people in Europe and the USA and is one of the most frequent reasons for patients to visit their primary care physician. Patients experiencing chronic pain often also have multiple other disorders and take…

Topical analgesia better than oral analgesia

Topical analgesia better than oral analgesia Professor Cruccu and colleagues studied the efficacy of a topical analgesic formulation of capsaicin and compared its effect with the oral intake of pregabalin (150–600 mg/day administered in two or three doses). They focused on the effects of both analgesic strategies on allodynia, a…

Chronic pain in the elderly leads to memory decline

Chronic pain in the elderly leads to memory decline Chronic pain is associated with accelerated memory decline and development of dementia in the elderly patients. According new findings, published in the last quarter of 2017, elderly patients suffering from chronic pain experienced an accelerated decline in functional independence. Elizabeth L….

Topical phenytoin gains momentum

Topical phenytoin gains momentum In a recent overview, published in the Pubmed indexed peer reviewed journal ‘Pain Management’ of November 2017: ‘Management of chronic neuropathic pain with single and compounded topical analgesics’ a number of references to the work of Topical Innovations on phenytoin cream can be found. In the introduction of…

Phenytoin inhibits inflammation in the skin

Phenytoin inhibits inflammation in the skin In dermatological conditions, topical phenytoin has been evaluated in the treatment of ulcers, epidermolysis bullosa, and in other inflammatory conditions of the skin. Topical phenytoin (2% to 5% in cream) was effective in treating the ulcers of epidermolysis bullosa simplex, and has also been…

Topical Analgesics in Real Life: results

Topical Analgesics in Real Life: results The results of a new study on topical analgesics ‘Optimizing Patient Experience and Response to Topical Analgesics (OPERA) Study’ was published in the Journal of Pain Research in October 2017. The results indicate that topical treatments may provide an effective and safer treatment alternative…