Phenytoin Topical Project ready to enter phase III after meeting with the Dutch Medicines Evaluation Board

Phenytoin Topical Project ready to enter phase III after meeting with the Dutch Medicines Evaluation Board In June 2018, a so called Tailored Advice Procedure at the Dutch Medicines Evaluation Board was initiated regarded the next developments steps of topical phenytoin cream. The aim of such development is to obtain registration for topical phenytoin cream…

Topical Analgesia Information welcomed at 3rd Eastern-European Pain Congress: 7−9 June 2018, Kiev, Ukraine

Topical Analgesia Information welcomed at 3rd Eastern-European Pain Congress: 7−9 June 2018, Kiev, Ukraine The topic ‘topical analgesics’ was hot during the at 3rd Eastern-European Pain Congress 2018, in Kiev, Ukraine. On 2 days (7th and 8th June) topics related to topical analgesia were presented, amongst others by Dr Roberto Casale, who focused on lidocaine…

9th International Conference on Clinical & Medical Case Reports: Keynote speech on n-of-1 case collections based on phenytoin cream in painful neuropathy

9th International Conference on Clinical & Medical Case Reports: Keynote speech on n-of-1 case collections based on phenytoin cream in painful neuropathy At the 9th International Conference on Clinical & Medical Case Reports September 27-28, 2018 at Amsterdam, the Netherlands the focus is: Role of Clinical & Medical Case Reports in redefining the Healthcare system…

Phenytoin: a new cytoprotective mechanism

Phenytoin: a new cytoprotective mechanism An impressive group of scientists from Germany, Spain, USA and France worked on discovering a new cellular mechanism of phenytoin, a mechanism leading to cellular protection [1]. They published the results in March 2018. We have described phenytoin’s protective mechanism on the level of nerve cells before [2,3], but these…

Topical analgesics can reduce opioid use

Topical analgesics can reduce opioid use Chronic, noncancer pain, among which neuropathic pain affects around 200 million people in Europe and the USA and is one of the most frequent reasons for patients to visit their primary care physician. Patients experiencing chronic pain often also have multiple other disorders and take many drugs. Unfortunately, most analgesics,…

Topical analgesia better than oral analgesia

Topical analgesia better than oral analgesia Professor Cruccu and colleagues studied the efficacy of a topical analgesic formulation of capsaicin and compared its effect with the oral intake of pregabalin (150–600 mg/day administered in two or three doses). They focused on the effects of both analgesic strategies on allodynia, a common peripheral neuropathic pain symptom.…