New Paradigm makes use of placebo controlled tests in daily practice: an innovation

The physicians of topical innovations have developed at their center in the Netherlands, patients a new placebo controlled test paradigm. In order to identify putative responders and exclude an (initial) placebo-response, first a single-blind and subsequently a double-blind placebo-controlled response tests has been developed. This test can be performed when the patient has a symmetrical…

Publication on topical analgesics

In the Dutch Pain Journal, “Nederlandstalig Tijdschrift Pijnbestrijding” we recently published an article about topical analgesia for the treatment of neuropathic pain. Read the whole artilce here.

English abstract

Old co-analgesics such as amitriptyline, ketamine and phenytoin are worth of being re-evaluated in compounded creams for the treatment of peripheral neuropathic pain. We call that process repositioning or repurposing. Read More…

Phenytoin cream at The EFIC 2018 Pain School Bergamo

The Pain Schools such as the upcoming Pain School at Bergamo, Italy, October 2018, are courses aimed at young (preferably under 45 years) European medical doctors and allied health professionals who are interested in further developing their knowledge and expertise in the field of pain management. The courses run for 4-5 days and include an…

Phentytoin cream finds its way into state of the art review

In the authorative Journal ‘Expert Opinion on Pharmacotherapy’, Prof. Terence J. Coderre wrote an impressive overview on topical drug therapy for neuropathic pain. Dr. Coderre is a Harold Griffith Professor in Anesthesia Research at McGill University. He is also the director of pain research laboratories in the Anesthesia Research Unit and at the MUHC Research…

Phenytoin Topical Project ready to enter phase III after meeting with the Dutch Medicines Evaluation Board

In June 2018, a so called Tailored Advice Procedure at the Dutch Medicines Evaluation Board was initiated regarded the next developments steps of topical phenytoin cream. The aim of such development is to obtain registration for topical phenytoin cream in Painful Diabetic Neuropathy. This tailor-made advice is customized advice mainly aimed at start-ups, small businesses…