TI presents first double-blind data supporting phenytoin 10% cream in painful polyneuropathies at FIGON Dutch Medicines Days

TI presents first double-blind data supporting phenytoin 10% cream in painful polyneuropathies at FIGON Dutch Medicines Days Every year FIGON (Federatie Innovatie Geneesmiddel Onderzoek Nederland: Dutch Federation Innovative Medicine Research) is organizing a 2-day conference. On the 23rd of September 2019 at  the FIGON Dutch Medicines Days David Kopsky on behalf of TI has presented…

Topical Innovation’s strategy supported: focus on broad-acting sodium channel blocker has higher likelihood of success

Topical Innovation’s strategy supported: focus on broad-acting sodium channel blocker has higher likelihood of success Nature’s review of April 8, 2019 is a further supportive piece of evidence for Topical Innovation’s strategy of developing a broad-acting sodium channel blocker as a topical treatment for neuropathic pain. Author Kingwell points out that despite compelling genetic validation,…

New Paradigm makes use of placebo controlled tests in daily practice: an innovation

New Paradigm makes use of placebo controlled tests in daily practice: an innovation The physicians of topical innovations have developed at their center in the Netherlands, patients a new placebo controlled test paradigm. In order to identify putative responders and exclude an (initial) placebo-response, first a single-blind and subsequently a double-blind placebo-controlled response tests has…

Topical Treatment of painful chemotherapy-induced neuropathy: new evidence

Topical Treatment of painful chemotherapy-induced neuropathy: new evidence Julien Rossignol et al. (2019) from Inserm and University Paris Descartes, Paris, France published a paper on the effects of high dose topical amitriptyline in painful chemotherapy-induced neuropathy: 10%. We advocated such high dose already years ago based on our clinical data. (Kopsky DJ, Hesselink JM (2012)…

Publication on topical analgesics

In the Dutch Pain Journal, “Nederlandstalig Tijdschrift Pijnbestrijding” we recently published an article about topical analgesia for the treatment of neuropathic pain. Read the whole artilce here.

English abstract

Old co-analgesics such as amitriptyline, ketamine and phenytoin are worth of being re-evaluated in compounded creams for the treatment of peripheral neuropathic pain. We call that process repositioning or repurposing. Read More…